Article
Δ20 IFITM2 differentially restricts X4 and R5 HIV-1.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2017
Wu Wan-Lin, Grotefend Christopher Robert, Tsai Ming-Ting, Wang Yi-Ling, Radic Vladimir, Eoh Hyungjin, Huang I-Chueh
Abstract excerpt
CCR5 (R5)-tropic, but not CXCR4 (X4)-tropic, HIV-1 is associated with primary HIV-1 infection and transmission. Recent studies have shown that IFN-induced transmembrane (IFITM) proteins, including IFITM1, IFITM2, and IFITM3, restrict a broad range of viruses. Here, we demonstrate that an IFITM2 isoform (Δ20 IFITM2) lacking 20 amino acids at the N terminus differentially restricts X4 and R5 HIV-1. Δ20 IFITM2...
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