Article

Inducible Nitric Oxide Synthase deficiency leads to early demyelination by altering the balance between pro- and anti-inflammatory responses against Murine-β-Coronavirus

2022-02-10

Abstract excerpt

The neurological disease Multiple sclerosis (MS) is characterized by neuroinflammation and demyelination orchestrated by the activated glial cells, the CNS infiltrating leukocytes, and their reciprocal interaction through inflammatory signals. Inducible nitric oxide synthase (iNOS), an enzyme that catalyzes sustained nitric oxide production in response to an inflammatory stimulus, is a pro-inflammatory marker expr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e4300c6-9868-5813-9bff-1663201ed577
DOI: 10.1101/2022.02.08.479662

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inducible Nitric Oxide Synthase deficiency leads to early demyelination by altering the balance between pro- and anti-inflammatory responses against Murine-β-CoronavirusDOI 10.1101/2022.02.08.479662Read

B cell-mediated immunomodulation by S-nitrosoglutathione (GSNO) in experimental autoimmune encephalomyelitisSemantic proximity Read

AIM2 inflammasome activation in astrocytes occurs during the late phase of EAESemantic proximity Read

Trem2 deficiency impairs recovery and phagocytosis by dysregulating myeloid gene expression during virus induced demyelinationSemantic proximity Read

The Role of Distinct Subsets of Macrophages in the Pathogenesis of MS and the Impact of Different Therapeutic Agents on These Populations.Semantic proximity Read

Ifit2 regulates murine-coronavirus spread to the spinal cord white matter and its associated myelin pathologySemantic proximity Read

Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis.Semantic proximity Read

Myeloid cell plasticity in the evolution of central nervous system autoimmunity.Semantic proximity Read

Patient-derived lymphocytes drive smoldering lesion pathology in a chimeric multiple sclerosis mouse modelSemantic proximity Read

Initial Immunopathogenesis of Multiple Sclerosis: Innate Immune ResponseSemantic proximity Read

Experimental Autoimmune Encephalomyelitis Is Exacerbated in Mice Lacking the <i>NOS2</i> GeneSemantic proximity Read

CD40 Signaling Restricts Retrograde Viral Spread and Provides Neuroprotection to Retinal Ganglion Cells in a Murine β-Coronavirus Model of Optic NeuritisSemantic proximity Read

IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis.Semantic proximity Read