Article

A binary trait model reveals the fitness effects of HIV-1 escape from T cell responses

2024-03-03

Abstract excerpt

Natural selection often acts on multiple traits simultaneously. For example, the virus HIV-1 faces pressure to evade host immunity while also preserving replicative fitness. While past work has studied selection during HIV-1 evolution, as in other examples where selection acts on multiple traits, it is challenging to quantitatively separate different contributions to fitness. This task is made more difficult becau...

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Literature Corpus work: 2a4adaf2-f9cc-5662-aa02-02a9b00a1e24
DOI: 10.1101/2024.03.03.583183

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