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Viral fitness: history and relevance for viral pathogenesis and antiviral interventions

1 Mar 2019

Abstract excerpt

The quasispecies dynamics of viral populations (continuous generation of variant genomes and competition among them) has as one of its frequent consequences variations in overall multiplication capacity, a major component of viral fitness. This parameter has multiple implications for viral pathogenesis and viral disease control, some of them unveiled thanks to deep sequencing of viral populations. Darwinian...

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PMID: 30980658
DOI: 10.1093/femspd/ftz021

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