Article
Evolution during primary HIV infection does not require adaptive immune selection.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2022
Swan David A, Rolland Morgane, Herbeck Joshua T, Schiffer Joshua T, Reeves Daniel B
Abstract excerpt
Modern HIV research depends crucially on both viral sequencing and population measurements. To directly link mechanistic biological processes and evolutionary dynamics during HIV infection, we developed multiple within-host phylodynamic models of HIV primary infection for comparative validation against viral load and evolutionary dynamics data. The optimal model of primary infection required no positive...
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