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Article

Modelling the evolution and spread of HIV immune escape mutants.

PLoS pathogens - 18 Nov 2010

Fryer Helen R, Frater John, Duda Anna, Roberts Mick G, Phillips Rodney E, McLean Angela R

Abstract excerpt

During infection with human immunodeficiency virus (HIV), immune pressure from cytotoxic T-lymphocytes (CTLs) selects for viral mutants that confer escape from CTL recognition. These escape variants can be transmitted between individuals where, depending upon their cost to viral fitness and the CTL responses made by the recipient, they may revert. The rates of within-host evolution and their concordant impact...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21124991
DOI: 10.1371/journal.ppat.1001196
PMCID: PMC2987822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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