Article
The route of HIV escape from immune response targeting multiple sites is determined by the cost-benefit tradeoff of escape mutations.
PLoS computational biology - 1 Oct 2014
Batorsky Rebecca, Sergeev Rinat A, Rouzine Igor M
Abstract excerpt
Cytotoxic T lymphocytes (CTL) are a major factor in the control of HIV replication. CTL arise in acute infection, causing escape mutations to spread rapidly through the population of infected cells. As a result, the virus develops partial resistance to the immune response. The factors controlling the order of mutating epitope sites are currently unknown and would provide a valuable tool for predicting conserved...
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