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Article

Comprehensive mapping of the virus and host factors that guide the paths of HIV-1 escape from a therapeutic.

Cell reports - 28 Jul 2026

Gillman Aaron N, Birler Cassian M, Vujjini Rohith Rao, Fili Mohammad, McCarthy-Potter Samuel A, Chen Wilson, Broghammer Madeline M, Hu Guiping, Gartland Margaret J, Prakash Manyu, Helverson Annika, Brown Grant G, Haim Hillel

Abstract excerpt

HIV-1 resistance to therapeutics can emerge through diverse mutational routes, yet the determinants guiding pathway selection in vivo remain unclear. Through comprehensive screening, we identify 18 mutations in the HIV-1 Env protein that enhance resistance to the FDA-approved small-molecule therapeutic temsavir. We then examine their occurrence in HIV-infected individuals who developed resistance on therapy....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42322610
DOI: 10.1016/j.celrep.2026.117558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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