Article
The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers.
Cell metabolism - 1 Dec 2010
Williams Siôn L, Huang Jia, Edwards Yvonne J K, Ulloa Rick H, Dillon Lloye M, Prolla Tomas A, Vance Jeffery M, Moraes Carlos T, Züchner Stephan
Abstract excerpt
Polg mtDNA mutator mice are important models for investigating the role of acquired mtDNA mutations in aging. Despite extensive study, there remains little consensus on either the etiology of the progeroid phenotype or the mtDNA mutation spectrum induced by disrupted polymerase-γ function. To investigate the latter, we have developed a novel, pragmatic approach we term "Mito-seq," applying next-generation...
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