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Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries

11 Mar 2025

Abstract excerpt

Importance: Age, sex, and apolipoprotein E (APOE) are the strongest risk factors for late-onset Alzheimer disease (AD). The role of APOE in AD varies with sex and ancestry. While the association of APOE with AD biomarkers also varies across sex and ancestry, no study has systematically investigated both sex-specific and ancestry differences of APOE on cerebrospinal fluid (CSF) biomarkers together, resulting in...

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PMID: 40067298
DOI: 10.1001/jamanetworkopen.2025.0562

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