Article

Lipid-driven SRC self-association modulates its transformation capacity

2024-11-12

Abstract excerpt

Src tyrosine kinase is anchored to the plasma membrane, however, the contribution of membrane lipids to its regulation remains elusive. Here we report Src self-association through a lysine cluster in the Src SH4 region mediated by lipids in human cells and in vitro. Mutation of the lysine cluster to arginine modulates Src self-association and its transforming function in human cells. This mechanism may also apply...

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Literature Corpus work: 2a033e0f-f548-57cd-9d9f-136908dad1cc
DOI: 10.1101/2024.11.12.623151

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