Article

Regulation of Src tumor activity by its N-terminal intrinsically disordered region

2021-05-10

Abstract excerpt

<h4>ABSTRACT</h4> The membrane anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src regulation relies on crystallography, which revealed intramolecular interactions to control active Src conformations. However, Src contains a N-terminal intrinsically disordered unique domain (UD) whose function remains unclear. Using NMR, we reported...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9693e10-fb2a-5f80-b117-57dcb040fb87
DOI: 10.1101/2021.05.10.443360

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulation of Src tumor activity by its N-terminal intrinsically disordered regionDOI 10.1101/2021.05.10.443360Read

Proteomic Analysis of Src Family Kinase Phosphorylation States in Cancer Cells Suggests Deregulation of the Unique Domain.Semantic proximity Read

Lipid-driven SRC self-association modulates its transformation capacitySemantic proximity Read

Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism.Semantic proximity Read

Lipid-driven Src self-association modulates its transformation capacity.Semantic proximity Read

The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases.Semantic proximity Read

Structural basis of constitutive c-Src kinase activity due to R175L and W118A mutations.Semantic proximity Read

A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular SignalingSemantic proximity Read

The impact of oncogenic mutations of the viral Src kinase on the structure and stability of the SH3 domain.Semantic proximity Read

SRC: Regulation, Role in Human Carcinogenesis and Pharmacological InhibitorsSemantic proximity Read

Allosteric networks governing regulation and catalysis of Src-family protein tyrosine kinases: implications for disease-associated kinases.Semantic proximity Read

Profiling of the drug resistance of thousands of Src tyrosine kinase mutants uncovers a regulatory network that couples autoinhibition to catalytic domain dynamicsSemantic proximity Read

The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding.Semantic proximity Read