Article

Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

2019-07-16

Abstract excerpt

<h4>Summary</h4> Receptor tyrosine kinase (RTK)-mediated activation of downstream effector pathways such as the RAS GTPase/MAP kinase (MAPK) signaling cascade is thought to occur exclusively from lipid membrane compartments in mammalian cells. Here, we uncover a membraneless, protein granule-based subcellular structure that can organize RTK/RAS/MAPK signaling in cancer. Chimeric (fusion) oncoproteins involving ce...

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Literature Corpus work: c1439827-6e8e-5604-8da1-c9044869b9ba
DOI: 10.1101/704312

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