Article

Conserved Structural Mechanism of Specific Recognition of the Histone Variant H2A.Z by the YL1 Subunit of SRCAP Chromatin-remodeling Complex

2025-04-25

Abstract excerpt

<title>Abstract</title> <p>The SRCAP complex regulates gene transcription through chromatin remodeling, where the subunit YL1 mediates the exchange of H2A-H2B dimers with H2A.Z-H2B in the nucleosome. We determined the high-resolution (2.01 Å) crystal structure of the N-terminal region (12-73) of the human SRCAP subunit YL1 in complex with H2B-H2A.Z, this domain termed as YL1-Z. YL1-Z consists of an alpha helix an...

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Literature Corpus work: c5e553d3-9ec2-5a7d-beb0-1009e1dc74bb
DOI: 10.21203/rs.3.rs-6500570/v1

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