Lipid-driven Src self-association modulates its transformation capacity.

Abstract excerpt

Src tyrosine kinase regulates cell growth and adhesion through membrane signaling, and its deregulation is associated with cancer. Although active Src is anchored to the plasma membrane, the role of membrane lipids in its regulation remains unclear. Here, we report that Src self-associates via a lysine cluster in its SH4 region, a process mediated by lipids in human cells and in vitro. Mutation of the lysine...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Membrane
• Share to Cell Transformation, Neoplastic