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Article

Allosteric networks governing regulation and catalysis of Src-family protein tyrosine kinases: implications for disease-associated kinases.

Clinical and experimental pharmacology & physiology - 1 Jan 2010

Cheng Heung-Chin, Johnson Timothy M, Mills Ryan D, Chong Yuh-Ping, Chan Khai-Chew, Culvenor Janetta G

Abstract excerpt

1. The Src-family protein tyrosine kinases (SFKs) are multidomain oncogenic protein tyrosine kinases. Their overactivation contributes to cancer formation and progression. Thus, synthetic inhibitors of SFKs are being developed as therapeutics for cancer treatment. Understanding the regulatory and catalytic mechanisms of SFKs is necessary for the development of therapeutic SFK inhibitors. 2. Although many upstream...

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Identifiers

PMID: 19566834
DOI: 10.1111/j.1440-1681.2009.05237.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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