Article

Phase-separation of EML4-ALK variant 3 is dependent upon an active ALK conformation

2020-06-11

Abstract excerpt

<h4>ABSTRACT</h4> Oncogenic fusions involving tyrosine kinases are common drivers of non-small cell lung cancer (NSCLC). There are at least 15 different variants of the EML4-ALK fusion, all of which have a similar portion of ALK that includes the kinase domain, but different portions of EML4. Targeted treatment with ALK tyrosine kinase inhibitors (TKIs) has proven effective but patient outcomes are variable. Here...

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Literature Corpus work: 63ed9d12-1ab8-5263-9606-6efa3859e5db
DOI: 10.1101/2020.06.11.144485

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