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Article

<i>In Vivo</i>Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell Kinase

9 May 2012

Abstract excerpt

ITK-SH3-mediated interactions, both with exogenous ligands and via intermolecular self-association with ITK-SH2, have been shown to be important for regulation of ITK activity. The biological significance of these competing SH3 interactions is not completely understood. A mutant of ITK where substitution of the SH3 domain with that of the related kinase BTK (ITK-BTK((SH3))) was used to disrupt intermolecular...

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Identifiers

PMID: 22649724
DOI: 10.1155/2012/694386

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