Article
Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases.
Genome research - 1 Nov 2011
Ritzerfeld Julia, Remmele Steffen, Wang Tao, Temmerman Koen, Brügger Britta, Wegehingel Sabine, Tournaviti Stella, Strating Jeroen R P M, Wieland Felix T, Neumann Beate, Ellenberg Jan, Lawerenz Chris, Hesser Jürgen, Erfle Holger, Pepperkok Rainer, Nickel Walter
Abstract excerpt
SRC proteins are non-receptor tyrosine kinases that play key roles in regulating signal transduction by a diverse set of cell surface receptors. They contain N-terminal SH4 domains that are modified by fatty acylation and are functioning as membrane anchors. Acylated SH4 domains are both necessary and sufficient to mediate specific targeting of SRC kinases to the inner leaflet of plasma membranes. Intracellular...
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