Article

Prevailing homozygous deletion of interferon and defensin genes in human cancers

2017-01-19

Abstract excerpt

Interferons and defensins are antimicrobial peptides that can also induce anti-tumor immunity. By analyzing the copy number profiles of 10,759 patients across 31 cancer types, we found the homozygous deletions of interferon and defensin genes are prevailing in most human cancers, and that patients with these homozygous deletions exhibited significant reduced overall survival or disease-free survival. We further de...

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Literature Corpus work: 29fcaef7-db7d-5392-ab5d-e19ad2febcfe
DOI: 10.1101/101741

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