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Article

Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populations.

Cell reports - 24 Feb 2026

Hu Xiaowen, Huang Jie, Yuan Jiao, Sun Yanrong, Wang Yuxin, Hu Zhongyi, Jiang Junjie, Wang Zhiling, Wang Bingwei, Long Meixiao, Maxwell Kara N, Fan Yi, Tanyi Janos L, Montone Kathleen T, Li Hongzhe, Kim Sarah H, Nathanson Katherine L, Rebbeck Timothy R, Domchek Susan M, Vonderheide Robert H, Zhang Lin

Abstract excerpt

As human populations migrated to diverse geographical regions, they encountered varying pathogens, leading to pronounced natural selection pressures on the immune system. Analysis of non-synonymous single-nucleotide polymorphisms (nsSNPs) across major geographically structured populations showed greater variation in immune-related genes than in non-immune genes, consistent with pathogen-driven selection, whereas...

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Genetic Variation
Membrane Proteins
Neoplasms
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41569853
DOI: 10.1016/j.celrep.2025.116882
PMCID: PMC13019158

Genes

STING1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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