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The Type I Interferonopathies

4 Nov 2016

Abstract excerpt

Type I interferons (IFNs) play a central role in the immune defense against viral infections. Type I IFN activation is induced by pattern-recognition receptors of the innate immune system that sense pathogen-derived nucleic acids. Cellular responses to type I IFN signaling are orchestrated by a complex network of regulatory pathways that involve both the innate and adaptive immune system. The genetic and...

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PMID: 27813875
DOI: 10.1146/annurev-med-050715-104506

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