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Signaling by Type I Interferons in Immune Cells: Disease Consequences

22 Apr 2024

Abstract excerpt

This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their...

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PMID: 38672681
DOI: 10.3390/cancers16081600

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