Article
Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency.
The Journal of allergy and clinical immunology - 1 Aug 2021
Vavassori Stefano, Chou Janet, Faletti Laura Eva, Haunerdinger Veronika, Opitz Lennart, Joset Pascal, Fraser Christopher J, Prader Seraina, Gao Xianfei, Schuch Luise A, Wagner Matias, Hoefele Julia, Maccari Maria Elena, Zhu Ying, Elakis George, Gabbett Michael T, Forstner Maria, Omran Heymut, Kaiser Thomas, Kessler Christina, Olbrich Heike, Frosk Patrick, Almutairi Abduarahman, Platt Craig D, Elkins Megan, Weeks Sabrina, Rubin Tamar, Planas Raquel, Marchetti Tommaso, Koovely Danil, Klämbt Verena, Soliman Neveen A, von Hardenberg Sandra, Klemann Christian, Baumann Ulrich, Lenz Dominic, Klein-Franke Andreas, Schwemmle Martin, Huber Michael, Sturm Ekkehard, Hartleif Steffen, Häffner Karsten, Gimpel Charlotte, Brotschi Barbara, Laube Guido, Güngör Tayfun, Buckley Michael F, Kottke Raimund, Staufner Christian, Hildebrandt Friedhelm, Reu-Hofer Simone, Moll Solange, Weber Achim, Kaur Hundeep, Ehl Stephan, Hiller Sebastian, Geha Raif, Roscioli Tony, Griese Matthias, Pachlopnik Schmid Jana
Abstract excerpt
BACKGROUND: Recognition of viral nucleic acids is one of the primary triggers for a type I interferon-mediated antiviral immune response. Inborn errors of type I interferon immunity can be associated with increased inflammation and/or increased susceptibility to viral infections as a result of dysbalanced interferon production. NFX1-type zinc finger-containing 1 (ZNFX1) is an interferon-stimulated double-stranded...
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