Article

Landscape and functional impact of missense mutations of immune response genes in human cancer

2025-08-07

Abstract excerpt

<title>Abstract</title> <p> Tumor-intrinsic defects in immune recognition and interferon-gamma (IFNγ) signaling pathways facilitate immune evasion and limit the efficacy of immune checkpoint blockade (ICB). Here, we delineate the mutational landscape and functional consequences of amino acid substitutions in key immune-related genes, <italic>B2M</italic> , <italic>CALR</italic> , <italic>IFNGR1</italic> ,...

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Literature Corpus work: a81d66a3-9a58-518c-b6a0-1fbaa7247265
DOI: 10.21203/rs.3.rs-7187015/v1

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