Article

Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers

2020-09-09

Abstract excerpt

Previous Thermostable Group II Intron Reverse Transcriptase sequencing (TGIRT-seq) found that human plasma contains short (≤300 nt) structured full-length excised linear intron RNAs (FLEXIs) with potential utility as blood-based biomarkers. Here, TGIRT-seq identified >9,000 different FLEXIs in human cells, including relatively abundant FLEXIs with cell-type-specific expression patterns. Analysis of published CLIP-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c950824-0f76-561a-9253-4109131dd034
DOI: 10.1101/2020.09.07.285114

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkersDOI 10.1101/2020.09.07.285114Read

Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak callingSemantic proximity Read

TGIRT-seq of Inflammatory Breast Cancer Tumor and Blood Samples Reveals Widespread Enhanced Transcription Impacting RNA Splicing and Intronic RNAs in PlasmaSemantic proximity Read

Intergenic RNA mainly derives from nascent transcripts of known genesSemantic proximity Read

The RNA Atlas, a single nucleotide resolution map of the human transcriptomeSemantic proximity Read

A pan-tissue, pan-disease compendium of human orphan genesSemantic proximity Read

Genome-wide identification of stable RNA-chromatin interactionsSemantic proximity Read

Cell type specific novel lincRNAs and circRNAs in the BLUEPRINT haematopoietic transcriptomes atlasSemantic proximity Read

Widespread intronic polyadenylation diversifies immune cell transcriptomesSemantic proximity Read

SCancerRNA: Expression at the Single Cell Level and Interaction Resource of Non-coding RNA Biomarkers for CancersSemantic proximity Read

Lnc2Cancer 3.0: an updated resource for experimentally supported lncRNA/circRNA cancer associations and web tools based on RNA-seq and scRNA-seq data.Semantic proximity Read

Genome-Wide Mapping of RNA-Protein Associations via SequencingSemantic proximity Read

Single Nucleus RNA Sequencing of Human Pancreatic Islets <i>In Vitro</i> and <i>In Vivo</i> Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional ProfileSemantic proximity Read