Article

Pervasive Intronic Polyadenylation Serves as a Potential Source of Cancer Neoantigens

2022-04-26

Abstract excerpt

<title>Abstract</title> <p>Tumor-specific neoantigens have emerged as a promising source for cancer immunotherapy. These tumor-specific neoantigens could arise from somatic mutations, aberrant splicing and RNA editing. Since intronic polyadenylation has similar potential as mutations to generate tumor-specific transcripts and peptides, it may serve as another neoantigen source, which has not been explored. We dev...

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Literature Corpus work: 72e75efc-8cb7-5d65-9d50-30a8f99b447e
DOI: 10.21203/rs.3.rs-1537870/v1

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