Article

Genetic determinants of monocyte splicing are enriched for disease susceptibility loci including for COVID-19

2024-07-11

Abstract excerpt

<title>Abstract</title> <p>Insights into variation in monocyte context-specific splicing and transcript usage are limited. We have performed paired gene and transcript QTL mapping across distinct immune states using RNA-seq of monocytes isolated from a cohort of 185 healthy Europeans incubated alone or in the presence of IFNγ or lipopolysaccharide (LPS). We identify regulatory variants to 5,749 genes and 8,727 tr...

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Literature Corpus work: 29e15bb4-6b68-5271-b2cb-6747e5debb93
DOI: 10.21203/rs.3.rs-4660781/v1

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