Article

Genetic determinants of blood gene expression and splicing and their contribution to molecular phenotypes and health outcomes

2023-11-27

Abstract excerpt

<h4>Summary</h4> The biological mechanisms through which most non-protein-coding genetic variants affect disease risk are unknown. To investigate the gene-regulatory cascades that ensue from these variants, we mapped blood gene expression and splicing quantitative trait loci (QTLs) through bulk RNA-sequencing in 4,732 participants, and integrated these data with protein, metabolite and lipid QTLs in the same indi...

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Literature Corpus work: 70f8009c-89c0-505e-a4e8-d049d5034076
DOI: 10.1101/2023.11.25.23299014

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