Article
Identification of context-dependent expression quantitative trait loci in whole blood.
Nature genetics - 1 Jan 2017
Zhernakova Daria V, Deelen Patrick, Vermaat Martijn, van Iterson Maarten, van Galen Michiel, Arindrarto Wibowo, van 't Hof Peter, Mei Hailiang, van Dijk Freerk, Westra Harm-Jan, Bonder Marc Jan, van Rooij Jeroen, Verkerk Marijn, Jhamai P Mila, Moed Matthijs, Kielbasa Szymon M, Bot Jan, Nooren Irene, Pool René, van Dongen Jenny, Hottenga Jouke J, Stehouwer Coen D A, van der Kallen Carla J H, Schalkwijk Casper G, Zhernakova Alexandra, Li Yang, Tigchelaar Ettje F, de Klein Niek, Beekman Marian, Deelen Joris, van Heemst Diana, van den Berg Leonard H, Hofman Albert, Uitterlinden André G, van Greevenbroek Marleen M J, Veldink Jan H, Boomsma Dorret I, van Duijn Cornelia M, Wijmenga Cisca, Slagboom P Eline, Swertz Morris A, Isaacs Aaron, van Meurs Joyce B J, Jansen Rick, Heijmans Bastiaan T, 't Hoen Peter A C, Franke Lude
Abstract excerpt
Genetic risk factors often localize to noncoding regions of the genome with unknown effects on disease etiology. Expression quantitative trait loci (eQTLs) help to explain the regulatory mechanisms underlying these genetic associations. Knowledge of the context that determines the nature and strength of eQTLs may help identify cell types relevant to pathophysiology and the regulatory networks underlying disease....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.