Article

MMR Deficiency Defines Distinct Molecular Subtype of Breast Cancer with Unique Proteomic Networks and Variable Clinical Significance

2022-04-15

Abstract excerpt

Mismatch repair (MMR) alterations are important prognostic and predictive biomarkers in a variety of cancer subtypes including colorectal and endometrial. However, in breast cancer (BC), the distinction and clinical significance of MMR is largely unknown. This may be due in part to the fact that genetic alterations in MMR genes are rare, and only seen to occur in around 3% of BCs. In the present study we analyzed...

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Literature Corpus work: 29d3b0c3-d8ad-5a10-b6ae-31dd85eaae1f
DOI: 10.1101/2022.04.14.488341

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