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Regulators of homologous recombination deficiency identified by machine learning using somatic multi-omics data.

Life science alliance - 1 Feb 2026

Valieris Renan, Rosa Lucas, Martins Luan, Defelicibus Alexandre, Carraro Dirce Maria, Nunes Diana Noronha, Dias-Neto Emmanuel, Rosales Rafael, da Silva Israel Tojal

Abstract excerpt

Homologous recombination deficiency (HRD) is a critical biomarker for guiding targeted therapies, yet the full range of somatic alterations driving HRD across cancers remains incompletely characterized. Here, we present a tumor-agnostic machine learning framework that integrates somatic multi-omics data, including copy-number variations, single-nucleotide variants, DNA methylation, and gene expression from over...

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Share to Biomarkers, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41260881
DOI: 10.26508/lsa.202503531
PMCID: PMC12631081

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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