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Multi-omics analyses unravel DNA damage repair-related clusters in breast cancer with experimental validation

31 Oct 2023

Abstract excerpt

Background: As one of the most common malignancies worldwide, breast cancer (BC) exhibits high heterogeneity of molecular phenotypes. The evolving view regarding DNA damage repair (DDR) is that it is context-specific and heterogeneous, but its role in BC remains unclear. Methods: Multi-dimensional data of transcriptomics, genomics, and single-cell transcriptome profiling were obtained to characterize the...

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PMID: 38022619
DOI: 10.3389/fimmu.2023.1297180

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