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Whole-Genome Sequencing Reveals Breast Cancers with Mismatch Repair Deficiency

13 Sept 2017

Abstract excerpt

Abstract Mismatch repair (MMR)–deficient cancers have been discovered to be highly responsive to immune therapies such as PD-1 checkpoint blockade, making their definition in patients, where they may be relatively rare, paramount for treatment decisions. In this study, we utilized patterns of mutagenesis known as mutational signatures, which are imprints of the mutagenic processes associated with MMR deficiency,...

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PMID: 28904067
DOI: 10.1158/0008-5472.can-17-1083

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