Article
The genetic landscape of metaplastic breast cancers and uterine carcinosarcomas.
Molecular oncology - 1 Apr 2021
Moukarzel Lea A, Ferrando Lorenzo, Da Cruz Paula Arnaud, Brown David N, Geyer Felipe C, Pareja Fresia, Piscuoglio Salvatore, Papanastasiou Anastasios D, Fusco Nicola, Marchiò Caterina, Abu-Rustum Nadeem R, Murali Rajmohan, Brogi Edi, Wen Hannah Y, Norton Larry, Soslow Robert A, Vincent-Salomon Anne, Reis-Filho Jorge S, Weigelt Britta
Abstract excerpt
Metaplastic breast carcinoma (MBC) and uterine carcinosarcoma (UCS) are rare aggressive cancers, characterized by an admixture of adenocarcinoma and areas displaying mesenchymal/sarcomatoid differentiation. We sought to define whether MBCs and UCSs harbor similar patterns of genetic alterations, and whether the different histologic components of MBCs and UCSs are clonally related. Whole-exome sequencing (WES)...
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