Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer

26 Sept 2016

Abstract excerpt

DNA repair genes and pathways that are transcriptionally dysregulated in cancer provide the first line of evidence for the altered DNA repair status in tumours, and hence have been explored intensively as a source for biomarker discovery. The molecular mechanisms underlying DNA repair dysregulation, however, have not been systematically investigated in any cancer type. In this study, we performed a statistical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27666291
DOI: 10.1038/srep34000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast CancerPMID 27666291Read ↗

Multi-omics analyses unravel DNA damage repair-related clusters in breast cancer with experimental validationSemantic proximity Read ↗

DNA Methylation Signatures in Breast Cancer: A Systematic Review and Meta-AnalysisSemantic proximity Read ↗

Aberrant epigenetic and transcriptional events associated with breast cancer riskSemantic proximity Read ↗

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancerSemantic proximity Read ↗

Prognostic analysis of patients with breast cancer based on tumor mutational burden and DNA damage repair genesSemantic proximity Read ↗

Signatures of DNA-Repair Deficiencies in Breast Cancer.Semantic proximity Read ↗

Damage-Net: A program for DNA repair meta-analysis identifies a network of novel repair genes that facilitate cancer evolution.Semantic proximity Read ↗

Regulators of homologous recombination deficiency identified by machine learning using somatic multi-omics data.Semantic proximity Read ↗

The Use of Mutational Signatures to Decipher the Inter-Relationship of Reactive Oxygen Species with Homologous Recombination and Non-Homologous End-Joining Deficiencies as Well as Their Effects on APOBEC Mutagenesis in Breast CancerSemantic proximity Read ↗

Aberrant expression of DNA damage response proteins is associated with breast cancer subtype and clinical featuresSemantic proximity Read ↗

Interplay Between Genetic and Epigenetic Changes in Breast Cancer Subtypes.Semantic proximity Read ↗

Identification of Breast Cancer Subtype-Specific Biomarkers by Integrating Copy Number Alterations and Gene Expression ProfilesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.