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Article

Identification of significantly mutated subnetworks in the breast cancer genome.

Scientific reports - 12 Jan 2021

Ajwad Rasif, Domaratzki Michael, Liu Qian, Feizi Nikta, Hu Pingzhao

Abstract excerpt

Recent studies showed that somatic cancer mutations target genes that are in specific signaling and cellular pathways. However, in each patient only a few of the pathway genes are mutated. Current approaches consider only existing pathways and ignore the topology of the pathways. For this reason, new efforts have been focused on identifying significantly mutated subnetworks and associating them with cancer...

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Identifiers

PMID: 33436820
DOI: 10.1038/s41598-020-80204-5
PMCID: PMC7804148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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