Article
Genetic interactions reveal distinct biological and therapeutic implications in breast cancer.
Cancer cell - 8 Apr 2024
Lin Cai-Jin, Jin Xi, Ma Ding, Chen Chao, Ou-Yang Yang, Pei Yu-Chen, Zhou Chao-Zheng, Qu Fei-Lin, Wang Yun-Jin, Liu Cheng-Lin, Fan Lei, Hu Xin, Shao Zhi-Ming, Jiang Yi-Zhou
Abstract excerpt
Co-occurrence and mutual exclusivity of genomic alterations may reflect the existence of genetic interactions, potentially shaping distinct biological phenotypes and impacting therapeutic response in breast cancer. However, our understanding of them remains limited. Herein, we investigate a large-scale multi-omics cohort (n = 873) and a real-world clinical sequencing cohort (n = 4,405) including several clinical...
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