Article
Exome analysis reveals differentially mutated gene signatures of stage, grade and subtype in breast cancers.
PloS one - 1 Jan 2015
Li You, Wang Xiaosheng, Vural Suleyman, Mishra Nitish K, Cowan Kenneth H, Guda Chittibabu
Abstract excerpt
Breast cancers exhibit highly heterogeneous molecular profiles. Although gene expression profiles have been used to predict the risks and prognostic outcomes of breast cancers, the high variability of gene expression limits its clinical application. In contrast, genetic mutation profiles would be more advantageous than gene expression profiles because genetic mutations can be stably detected and the mutational...
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