Article

Limited bone marrow chimerism impairs cell competition in the thymus and causes leukemia

2025-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Cell competition in the thymus is a critical tumor suppressor process that prevents leukemia. We show that suboptimal bone marrow correction of γ c -deficient mice disrupts this process, inducing thymus autonomy and promoting T cell acute lymphoblastic leukemia (T-ALL). γ c -deficiency causes severe combined immunodeficiency in mice and humans and is treated by hematopoietic stem and progeni...

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Literature Corpus work: 29c9fddd-a074-543c-b822-fe7c1e6637d4
DOI: 10.64898/2025.12.16.694652

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