Article
NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.
PloS one - 1 Jan 2012
Ma Wenxue, Gutierrez Alejandro, Goff Daniel J, Geron Ifat, Sadarangani Anil, Jamieson Christina A M, Court Angela C, Shih Alice Y, Jiang Qingfei, Wu Christina C, Li Kang, Smith Kristen M, Crews Leslie A, Gibson Neil W, Deichaite Ida, Morris Sheldon R, Wei Ping, Carson Dennis A, Look A Thomas, Jamieson Catriona H M
Abstract excerpt
BACKGROUND: Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutations in signaling pathways, such as NOTCH1, that promote self-renewal and survival within supportive niches. Activating mutations in NOTCH1 occur commonly in T cell acute lymphoblastic leukemia (T-ALL) and have been implicated in therapeutic resistance. However, the cell type and context specific...
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