Article

Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T lymphocyte acute lymphoblastic leukemia

2023-04-25

Abstract excerpt

<h4>ABSTRACT</h4> T lymphocyte acute lymphoblastic leukemia (T-ALL) is frequently associated with increased expression of the E protein transcription factor inhibitors TAL1 and LYL1. In mouse models, ectopic expression of Tal1 or Lyl1 in T cell progenitors or inactivation of E2a, is sufficient to predispose mice to develop T-ALL. How E2a suppresses thymocyte transformation is currently unknown. Here, we show that...

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Literature Corpus work: 1d8b5286-affd-5b18-a3c6-d94fbd536b06
DOI: 10.1101/2023.04.23.537993

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