Article

Convergent clonal selection of donor- and recipient-derived CMV-specific T cells in hematopoietic stem cell transplant patients

2021-09-15

Abstract excerpt

Competition between antigen-specific T cells for peptide:MHC (p:MHC) complexes shapes the ensuing T cell response. Mouse model studies provided compelling evidence that competition is a highly effective mechanism controlling the activation of naïve T cells. However, assessing the effect of T cell competition in the context of a human infection requires defined pathogen kinetics and trackable naïve and memory T cel...

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Literature Corpus work: d9d2b801-2a30-5152-8017-0f16094204a5
DOI: 10.1101/2021.09.14.458942

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