Article

Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

2024-06-29

Abstract excerpt

<h4>ABSTRACT</h4> The discovery of genetic alterations in patient samples over the last decades has reinforced a cell-autonomous view of proliferative expansion during T- cell acute lymphoblastic leukemia (T-ALL) development in the thymus. However, the potential contribution of non-cell-autonomous factors, particularly the impact of thymic epithelial cells (TECs) within the thymic niche during the initiation phas...

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Literature Corpus work: 69c3362b-fcfb-51b0-ab01-1fc9f0d0cabd
DOI: 10.1101/2024.06.25.600590

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