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Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition

23 Feb 2023

Abstract excerpt

Cell competition has recently emerged as an important tumor suppressor mechanism in the thymus that inhibits autonomous thymic maintenance. Here, we show that the oncogenic transcription factor Lmo2 causes autonomous thymic maintenance in transgenic mice by inhibiting early T cell differentiation. This autonomous thymic maintenance results in the development of self-renewing preleukemic stem cells (pre-LSCs) and...

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PMID: 36920307
DOI: 10.1084/jem.20212383

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