Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

Genes & development - 1 Jun 2010

Tremblay Mathieu, Tremblay Cédric S, Herblot Sabine, Aplan Peter D, Hébert Josée, Perreault Claude, Hoang Trang

Abstract excerpt

Deciphering molecular events required for full transformation of normal cells into cancer cells remains a challenge. In T-cell acute lymphoblastic leukemia (T-ALL), the genes encoding the TAL1/SCL and LMO1/2 transcription factors are recurring targets of chromosomal translocations, whereas NOTCH1 is activated in >50% of samples. Here we show that the SCL and LMO1 oncogenes collaborate to expand primitive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen Presentation
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD3 Complex

Share to LIM Domain Proteins

Share to Major Histocompatibility Complex

Share to Receptor, Notch1

Share to T-Cell Acute Lymphocytic Leukemia Protein 1

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 20516195
DOI: 10.1101/gad.1897910
PMCID: PMC2878648

Genes

LMO1
NOTCH1
TAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.PMID 20516195Read ↗

SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.Semantic proximity Read ↗

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALLSemantic proximity Read ↗

Friend or foe: can activating mutations in NOTCH1 contribute to a favorable treatment outcome in patients with T-ALL?Semantic proximity Read ↗

Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competitionSemantic proximity Read ↗

Disordered T-Cell Development and T-Cell Malignancies in SCL LMO1 Double-Transgenic Mice: Parallels with E2A-Deficient MiceSemantic proximity Read ↗

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.Semantic proximity Read ↗

NOTCH1-Induced T-Cell Acute Lymphoblastic Leukemia In Vivo Models.Semantic proximity Read ↗

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.Semantic proximity Read ↗

Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in a Murine Model of T Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model.Semantic proximity Read ↗

The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia.Semantic proximity Read ↗

Altered thymic niche synergistically drives the massive proliferation of malignant thymocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.