Article
Identification of checkpoints in human T-cell development using severe combined immunodeficiency stem cells.
The Journal of allergy and clinical immunology - 1 Feb 2016
Wiekmeijer Anna-Sophia, Pike-Overzet Karin, IJspeert Hanna, Brugman Martijn H, Wolvers-Tettero Ingrid L M, Lankester Arjan C, Bredius Robbert G M, van Dongen Jacques J M, Fibbe Willem E, Langerak Anton W, van der Burg Mirjam, Staal Frank J T
Abstract excerpt
BACKGROUND: Severe combined immunodeficiency (SCID) represents congenital disorders characterized by a deficiency of T cells caused by arrested development in the thymus. Yet the nature of these developmental blocks has remained elusive because of the difficulty of taking thymic biopsy specimens from affected children. OBJECTIVE: We sought to identify the stages of arrest in human T-cell development caused by...
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