Article

Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL

2023-07-20

Abstract excerpt

<title>Abstract</title> <p>Malignant transformation of T-cell progenitors causes T-cell acute lymphoblastic leukemia (T-ALL), an aggressive childhood lymphoproliferative disorder. Activating mutations of Notch1 and overexpression of Notch3, as well as rare Notch3 activating mutations have been detected in T-ALL patients. In this study, we aimed to deeply characterize major steps contributing to the progression of...

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Literature Corpus work: e4e443e6-e710-5103-8606-73fe5e08a5ce
DOI: 10.21203/rs.3.rs-3167384/v1

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