Article

Generation of Functional Human T Cell Development in NOD/SCID/IL2rγ <sup>null</sup> Humanized Mice Without Using Fetal Tissue: Application as a Model of HIV Infection and Persistence

2022-05-30

Abstract excerpt

Generating humanized mice with fully functional T cells currently relies on co-implantation of hematopoietic stem cells from fetal liver and autologous fetal thymic tissue (BLT mouse). However, access to such tissues has ethical and logistical challenges. Herein, we show that NOD/SCID/IL2rγ null mice humanized with cord blood-derived CD34 + cells and implanted in quadriceps with pediatric thymic tissues excised...

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Literature Corpus work: 9f642e74-42fe-51dd-beb4-0127865fd9d9
DOI: 10.1101/2022.05.30.494009

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Generation of Functional Human T Cell Development in NOD/SCID/IL2rγ <sup>null</sup> Humanized Mice Without Using Fetal Tissue: Application as a Model of HIV Infection and PersistenceDOI 10.1101/2022.05.30.494009Read

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