Article

A minimal sequence motif drives selective tRNA dihydrouridylation by hDUS2

2023-11-05

Abstract excerpt

<h4>ABSTRACT</h4> The post-transcriptional reduction of uridine to dihydrouridine (D) by dihydrouridine synthase (DUS) enzymes is among the most ubiquitous transformations in RNA biology. D is found at multiple sites in tRNAs and studies in yeast have proposed that each of the four eukaryotic DUS enzymes modifies a different site, however the molecular basis for this exquisite selectivity is unknown and human DUS...

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Literature Corpus work: 29b0785a-8085-5001-ba09-d1d987482560
DOI: 10.1101/2023.11.04.565616

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